Research from the Department of Chemistry and Biochemistry has produced several articles in several major journals in recent months. Undergraduate and graduate student coauthors were prominently involved in many of the studies.
In December of 2017, Prof. Kyle Grice and five DePaul student coauthors published a paper in New Journal of Chemistry studying the behavior of drug molecules, in collaboration with colleagues at Rosalind Franklin University and North Carolina State University.The research team used NMR, reactivity testing, absorbance spectroscopy, fluorescence spectroscopy, X-Ray crystallography, and computational methods to study the compounds. They determined that a C-S bond was very weak because of the favorable formation of a carbocation upon cleavage. This result may explain some of the biological activities of these molecules as well.
Prof. Paul Vadola and five DePaul students published an article in the Journal of Organic Chemistry in January reporting a catalytic redox-neutral method for the synthesis of spirolactams, proceeding through the dearomative spirocyclization of N-aryl alkynamides. They were able to achieve selective spirocylcization with 35-87% yields and broad substrate scope.
Profs. Caitlin Karver and Carey Southern published a collaborative paper in February 2018 in the journal Analytical Biochemistry , with four DePaul student coauthors. They were able to develop a new assay for monitoring inflammatory caspase activity, relying on energy transfer between a tryptophan coumarin amino acid side chains. This methodology will allow for C-terminal amino acids to be included in peptide substrates. They were able to find activity differences with minor sequence modifications on the C-terminus with one enzyme, and will be able to develop a substrate specificity/selectivity pattern for all of the inflammatory caspases in the future.
Profs. Kyle Grice and Graham Griffin published a collaborative paper in the Journal of Physical Chemistry A in March of 2018, along with four DePaul student coauthors. Their study reveals the solution phase structure, electronic structure, and electronic dynamics of a metal-ligand complex that has applications in OLEDs and other organic electronic technologies.
Profs. Wendy Wolbach and Timothy French were co-authors on two papers recently published on a significant bio-mass burning episode 12,800 years ago (a cosmic impact caused a really really big fire!). Both papers were published in the Journal of Geology (second paper) and the articles got some press coverage as well!
Congratulations to all of the authors, we are very proud of their hard work and great achievements!