Martin Conda-Sheridan
Assistant Professor
Pharmaceutical Sciences
University of Nebraska Medical Center
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Friday, September 14 at 1PM in McGowan South 103
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Synthesis and antimicrobial evaluation of the Endophenazines and their analogues
ABSTRACT:
Hospital- and community-associated bacterial infections caused by pathogens such as methicillin-resistant staphylococcus aureus (MRSA) and escherichia coli (E. coli) are a reason of concern to people in the USA and around the world. These infections have become increasingly difficult to treat due to the tendency of bacteria to develop resistance and to form biofilms. Our lab is developing an antibacterial program using the phenazine natural products as active scaffolds. In this talk, we will introduce the total synthesis of two members of the endophenazine family. We will also present their biological activity against MRSA, E.coli and their toxicity towards human cells. In addition, we will present preliminary studies to unravel the mechanism of action of the molecules and the ability of bacteria to develop resistance to the molecules. Finally, we will present data regarding their metabolic stability.
The Catalyst 